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Hydroxyl radical ( OH) is taken into account as the most potent oxidant which, owing to its short half-life, very positive redox potential (close to +2 V) and high affinity for biomolecules, non-selectively oxidize DNA, proteins, lipids, amino acids, sugars, and metals, leading to damage or genetic instability

P38 is a major pathway influencing cell proliferation, cell cycle, and apoptosis, and is activated in response to various environmental stresses, involving inflammatory cytokines, oxidative and nitrosative stress, and DNA damage (Shahab and Jamesdaniel 2022

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