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A recent review of the biological rationale and evidence for considering pregabalin for the management of symptoms of CIPN concluded that pregabalin is not likely to prevent CIPN, but shows promise for treatment of established CIPN (Davis 2022)

4 In another study evaluating topical glutathiones role on UV-induced erythema, Grandi et al 9 found that subjects pre-treated with S-acyl glutathione 2% cream, a linoleic acid pre-conjugate, had a significantly lower minimal erythema dose compared to placebo, indicating UV protective properties ( p =0.0003)

Deletion of Kalirin-7 in mice resulted in schizophrenia-like phenotypes (Newey et al., 2005

Natural antioxidants, or secondary metabolites, are widely used in diets and have no side effects on the immune system

Conclusions In summary, a three-pathway combinatorial method of GSH biosynthesis presents higher GSH yield and utilization efficiency of amino acid precursors than that of a single pathway

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