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T cell exhaustion represents a considerable challenge in cancer treatment

OBrien, N

Platelet activation triggers further leukocyte activation and promote RBC adhesion to an exposed endothelium ( ex vivo studies, and was well tolerated by patients, but on a 24-month follow up, patients on the treatment arm failed to show reduction in the frequency of VOC (Kanter et al., 2019) (ClinicalTrials.gov identifier: NCT02482298)