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Meanwhile, cellular component (CC) analysis showed that these defense-related proteins were primarily localized in the extracellular region, suggesting their secretion for extracellular defense functions

Strong family history of hormone-sensitive cancers or genetic predisposition (BRCA1/2, Lynch syndrome): Elevated IGF-1 carries meaningful epidemiological risk that outweighs potential benefit without oncology clearance

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However, IRF3-5D (an active phosphomimetic mutant of IRF3 in which the phosphomimetic aspartate replaced S396, S398, S402, S404, and S405 [40], Fig