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SKU: 62095363121
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Espunya MC, Daz M, Moreno-Romero JORDI, Martnez MC (2006) Modification of intracellular levels of glutathionedependent formaldehyde dehydrogenase alters glutathione homeostasis and root development

Snoddy, L

doi: 10.3748/wjg.v21.i29.8787 69

Here, we report DJX-A-KM, a small-molecule degrader of KRAS G12C , designed by incorporating an acrylamide warhead into the MRTX849 scaffold

Nonetheless, well-designed clinical trials and in vitro studies are needed to clarify its mechanisms of action, establish optimal dosing, and evaluate safety and long-term efficacy in human populations