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ROS can also indirectly disrupt the gut barrier by significantly reducing the expression of tight junction proteins such as ZO-1, Occludin, and Claudin-4 [153]

10.1016/j.fitote.2014.08.007 270 ZhuY.WangS.XuA

doi:10.1016/S2213-2600(13)70187-5 12

They reinforce the critical and primary role of beta cells in disease initiation and progression, with many risk variants controlling genes that regulate beta cell development, function and stress resilience

J Clin Oncol 25(18S):14101, 2007

(2) Metabolic pathway differences: certain microbial metabolites observed in animal models (such as specific indole derivatives) may differ in production levels and metabolic pathways in humans (52)