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Polioencephalomalacia More commonly called goat polio or simply thiamine deficiency, polioencephalomalacia is a neurological disease characterized by brain swelling and tissue death the word literally means softening of the brain. Ruminants harbor beneficial bacteria and protozoa that produce Vitamin B12 (cobalamin) and Vitamin B1 (thiamine) under normal environmental conditions

Elia AE, Bagella CF, Ferre F, Zorzi G, Calandrella D, Romito LM

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NICE 2019)

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Poor sleep can increase NNMT expression and reduce NAD+ levels, potentially counteracting some benefits of 5-amino-1mq