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In plasma, tacrolimus binds to 1-acid glycoprotein and albumin with high affinity

Lastly, mitochondria are crucial for maintaining calcium homeostasis in cells, which is essential for various cellular functions, including muscle contraction, nerve impulse transmission, and hormone secretion

hTauT adopts the canonical LeuT fold with 12 transmembrane helices (TM1-12), resolved with clear side chains (Fig

Ponton et al

This underscores the need to explore alternative chemotypes with improved zinc-coordination behavior

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