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Further clinical studies are required to establish the usefulness of L-carnitine supplementation in hypothyroidism (see Table 1 )

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Accumulation of reactive fatty acids leads to mitochondria -oxidation imbalance that subsequently contributes to liver inflammatory injury and increased expression of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor- (TNF-), MCP-1, and IL-1, that further exacerbate SHBG depletion [52]

L-carnitine (or D-carnitine) content detection of the present invention, wherein the above mentioned chromatographic conditions of step (1) comprise a mobile phase which is a mix of the triethylamine buffer (phosphate 8 ml, triethylamine, 15 ml, water 1500 ml) and tetrahydrofuran

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Multiple sessions may be needed to achieve your desired results