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Moreover, ABX-induced depressed mice exhibited notable differences in the abundance of gut microbiota, neurobiological factors, and functional gene abundance ( 3 FMT in alleviating depression via microbial-gut-brain axis The bidirectional communication between the brain and gut microbiota is achieved through multiple pathways, including the vagus nerve, neuroendocrine system, neuroimmune system, and autonomic nervous system ( FMT represents an innovative therapeutic modality centered on the extraction, purification, and isolation of beneficial microbial consortia from the feces of healthy donors, followed by their transplantation into the gastrointestinal tract of recipients ( Clostridium difficile infection , and preventing its relapse ( The gut microbiota serves as a critical mediator of bidirectional gut-brain communication, potentially influencing mood regulation and cognitive behavior ( The vagus nerve is the primary neural conduit between the brain and the gastrointestinal tract, playing a crucial role in modulating gut activity and conveying visceral sensory signals to the brain

Circadian regulation of hepatic cytochrome P450 2a5 by peroxisome proliferator-activated receptor

Luc JG, Fowler CS, Eisenberg SB, Estrera AL, Wolf RK, Choi CW, Lawton JS, Martin LW, Nesbitt JC, Reznik SI, Nguyen TC, Vaporciyan AA, Antonoff MB

Transcriptome analysis has revealed that high-density neutrophils (HDNs) and LDNs have opposite transcriptome profiles