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The induction of PI3K-Akt-eNOS signaling mediated by the binding of ApoA-1 and SR-B1 up-regulates cyclooxygenase (COX-2) expression and prostaglandin I2 (PGI 2 ) release in ECs (225)

The GAA triplet-repeat sequence in Friedreich ataxia shows a high level of somatic instability in vivo, with a significant predilection for large contractions