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Deficiencies in BB 2 and/or bb 3 do not influence feeding, although the hypophagic response to low-dose bombesin is suppressed in BB 2 -deficient mice

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It has not been established through a controlled in-vivo human trial

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Studies, including research from the National Institute on Drug Abuse (NIDA), show that repeated opioid exposure leads to structural brain changes, increasing the risk of addiction