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A cluster of male pseudohermaphrodites with 5-reductase deficiency in Papua New Guinea

the change in the number of nocturia episodes per 24 hours was -21.7 (p=0.001) and -1.51.8 (p=0.003) and the mean voided volume improved from 95 to 176 mL, and from 99 to 174 mL in those with and without nocturnal polyuria, respectively

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One placebo-controlled trial of 4.5 mg LDN nightly showed statistically significant improvements in mental health and pain scales.[ref] However, another placebo-controlled trial, though, showed no statistical difference between LDN and placebo in MS patients.[ref] In a review of six trials of LDN in MS, four out of six had positive results.[ref] LDN for pain and fibromyalgia: At low doses, naltrexone has a pain-relieving effect

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10.1038/s41598-020-77328-z 72 HosseiniS.GhadimiM.ReyhaniN.KhazaeiS.Rahmatkhah-YazdiM.Soleimani-FarsaniR.et al (2025)