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Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the typical outcome of CKD, and represents a growing public health burden and is the leading cause of ESRD [4, 5]

Hirasawa A, Hara T, Katsuma S, Adachi T, Tsujimoto G

Morse MA, Wang C, Stoner GD, Mandal S, Conran PB, Amin SG, et al

Carcinoma cells, for instance, form colonies in 3D gels, whereas immortalized NIH-3T3 fibroblasts do not [26, 27]

Sodium/hydrogen exchanger 3 (NHE3) inhibitor (Tenapanor): Shown to reduce abdominal pain and bloating in IBS-C by modulating sodium transport and visceral sensitivity, though long-term safety remains under investigation [114,115,116]

This indicates its potential to repair H 2 O 2 -induced oxidative stress damage in HepG2 cells