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Ectopic lesions show significant volumetric regression, while systemic and local production of key pathological mediators, including tumor necrosis factor-alpha (TNF-), vascular endothelial growth factor (VEGF), and matrix metalloproteinase-2 (MMP-2), is markedly reduced

Triglyceride (TG) deposition, indicative of aberrant hepatic lipid metabolism, is driven primarily by free fatty acids (FFAs) originating from adipose tissue and de novo lipogenesis (DNL)