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According to Global Burden of Diseases (GBD) data survey statistics, depression is one of the leading causes of disability-adjusted life years (DALYs) for people aged 1049 years (1024 years: fourth, 2549 years: Sixth) (Whiteford et al., 2013)

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Liver-specific Igf1 knock-out mice continued to grow normally despite reduction in circulating IGF-I, indicating that locally produced IGF-I was an important growth mediator (Yakar et al., 1999)