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Research has found that excessive accumulation of lipid peroxidation products in the cell membrane can lead to the inactivation of Na/K-ATPase, resulting in a high intracellular Na state and exacerbating the cytoplasmic univalent cation gradient [102]

In patients over two years of age who are clinically suspected of having a hereditary mitochondrial disease, Depakote should only be used after other anticonvulsants have failed

10.1038/ijo.2009.99 66 FerreraL.BarbieriR.PiccoC.ZuccoliniP.RemiganteA.BertelliS.et al (2021)

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