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Experts Recommendations for Therapeutic Landscapes The extended use of metformin, a key player in preventing type 2 diabetes among individuals with prediabetes, has been associated with vitamin B 12 deficiency, particularly concerning for specific subgroups such as those with a BMI of 35 kg/m 2 , individuals below the age of 60, and women with prior gestational diabetes mellitus [46]

Results Literature Review Twenty-three articles met the inclusion criteria

Mol Pharmacol (2000) 58(4):67783

Gutbrain axis: role of gut microbiota on neurological disorders and how probiotics/prebiotics beneficially modulate microbial and immune pathways to improve brain functions