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Therefore, it is not enough to target one transporter alone in cancer treatment

Identification of AURKA as a biomarker associated with cuproptosis and ferroptosis in HNSCC

FIGURE 3 Alternatively, during specific conditions, where complex I is destabilized or the ubiquitination process is inhibited, RIPK1 dissociates from complex I and binds to Fas-associated death domain (FADD) and caspase-8, forming apoptotic complex II that results in induction of TNF--induced apoptosis (Seifert and Miller, 2017