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10.1007/s40263-013-0138-y 51 FerreiraA

Beyond modulating the metabolic and immune environments of tumors, targeting tumor matrix remodeling has emerged as a novel therapeutic strategy

Inconsistencies in oxidative stress and antioxidant defense measurements undermine the results reliability

Leber's Hereditary Optic Neuropathy (LHON)

Mutations in the gene encoding OCTN2, SLC22A5 , can impair fatty acid metabolism and lead to systemic primary carnitine deficiency (SPCD, OMIM 212140) 8 , an autosomal recessive disorder whose clinical manifestations include cardiomyopathy, hypoglycemia, chronic muscle weakness and liver dysfunction 9

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