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This enhanced vascularization brings more oxygen and nutrients to damaged tissues, accelerating repair

Small 6 , 811817 (2010)

10.1016/j.biopha.2025.118349 2 Al-SmadiK.ImranM.AbdohA.LiuD.PhanK.FilhoN

In a case-control study involving smokers with normal lung function, COPD, and lung cancer (COPD subtype), it was found that the GG genotype of the rs1489759 HHIP SNP and the CC genotype of the rs2202507 GYPA SNP exhibited a protective effect against both COPD (OR 0.59, p = 0.006 for HHIP and OR = 0.65, p = 0.006 for GYPA) and lung cancer (OR = 0.70, p = 0.05 for HHIP and OR = 0.70, p = 0.02 for GYPA) [139]

Oxidative stress also promotes cellular aging by affecting the cellular redox state and post-translational modifications, such as DNA damage and protein oxidation

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