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The principal regulatory mechanisms orchestrating ferroptosis encompass lipid peroxidation, amino acid metabolism, oxidative stress, iron ion homeostasis, and diverse organelles, all constituting prerequisites for the manifestation of ferroptosis to occur

Repeated weight cycling in obese mice causes increased appetite and glucose intolerance

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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

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The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda