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Common (Generally Mild) Nausea Vomiting Headache Mild sedation GI discomfort related to PN Metabolic Effects Elevated homocysteine (risk factor for thrombosis) Metabolic acidosis Hyperammonemia (especially in hepatic dysfunction) Elevated BUN/creatinine Hyperglycemia (from PN carbohydrates) Rare / Serious Hepatic dysfunction Allergic reactions to PN components Central line complications (infection, thrombosis) Refeeding syndrome (hypophosphatemia, hypokalemia, hypomagnesemia) Neurologic symptoms if severe ammonia elevation occurs Pregnancy & Breastfeeding Pregnancy Methionine is naturally required in pregnancy, and PN is considered safe and appropriate when medically indicated

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Dopamine multilocus genetic profile influence on reward network in chronic insomnia disorder with depression

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PD is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta and the presence of aggregated, intracellular inclusions containing -synuclein, termed Lewy bodies [199]

10.1002/(SICI)1097-4547(20000215)59:4 3.0.CO;2-9 Summary Keywords zebrafish, hair cell protection, hearing loss, aminoglycosides, hepatocyte growth factor, lateral line Citation Uribe PM, Kawas LH, Harding JW and Coffin AB (2015) Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure