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Acknowledgements This study was supported by Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2024MSXM069), Sponsored by Natural Science Foundation of Chongqing (CSTB2023NSCQ-MSX0078), National Natural Science Foundation of China (82404174)

They are formulated with high-quality ingredients and manufactured under strict quality control standards to ensure safety and efficacy

Mounjaro and Ozempic both target appetite regulation and can lead to significant weight loss

THP-1 cell culture Human acute monocytic leukemia cell line (THP-1) is purchased from Merck and cultured in RPMI containing FCS (10%) and penicillin-streptomycin (1%)

Marasco MR, Conteh AM, Reissaus CA, Cupit JEt, Appleman EM, Mirmira RG, Linnemann AK

Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain. J Cell Biol 126(2): 485-94