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Epidemiological studies indicate that approximately 20%40% of diabetic patients develop DKD during the course of their disease, with a considerable proportion ultimately requiring renal replacement therapy (3)

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In addition to the enteric neurons, microbial colonization enables early postnatal EGC maturation ( Although many ENS functions are independent of CNS input, the ENS does function as an interface to detect intestinal luminal cues that trigger upstream CNS signaling pathways