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VPA is also known to modulate gene expression via inhibition of histone deacetylase 56 , and in particular, VPA has been shown to reduce expression of NLGN3 57 , thus mimicking the effect of the genetic manipulation in Nlgn3 R451C KI mice and Nlgn3 KO rats

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If the trial had low risk for all domains, a high-quality study was considered a low risk of bias

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The significance of these findings lies in the comprehensive understanding of Hgs impact on organ, tissue, cellular, and molecular functioning leading to cardiovascular dysfunction