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Many users begin to notice improvements in their skin within 4-8 weeks of consistent use

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Additionally, altered DSIP responses in major depression and suicidal patients suggest its role in addressing dysregulated stress in mood disorders (5)

Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

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