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Therefore, the effect of autophagy on ferroptosis in cancer cells depends on the specific context and conditions of the tumor microenvironment

We found that ACE not only increased Fe 2+ levels by targeting PCBP1 and PCBP2 but also targeted GPX4 leading to its degradation by the ubiquitin-proteasome pathway

Studies with supplementation of non-isoprenoid CoQ analogs indicate that the isoprenoid tail is essential for efficient uptake and growth rescue of coq mutants in a non-fermentable medium

After exposure, the cells were divided into two groups: (a) those were analyzed immediately, without the possibility of regeneration, to note the potential direct negative effect of EMF on the cells, and (b) those regenerated for 30 h under standard culture conditions, during which there should have been cell doubling and the production of a new daughter generation

AACR Annual Meeting 2024 84(17), 2024