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A comparison of c-MET-driven and c-MET independent GIC models revealed that TGF- inhibits stemness in GIC at least in part via its negative regulation of c-MET activity, suggesting that stem cell (SC) maintenance may be controlled by the balance between these two oncogenic pathways

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Gastrointestinal adverse events occurred in 79.6% of CagriSema participants versus 39.9% with placebo, were mostly transient, and led to discontinuation in 6-8.4% of participants