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Studies have suggested that the uptake of HMCD complexes, including MHI-148-HSA and genistein-IR-783 conjugates, could be mediated by micropinocytosis and lipid-raft endocytosis ( Figure 2 ) (58, 74)

FIGURE 5 In electromechanical coupling, membrane depolarization leads to an increase in [Ca 2+ ] (c) due to calcium influx from the extracellular space through voltage-dependent calcium channels (Ca V ), ultimately initiating the contraction process (Hill-Eubanks et al., 2011) (Figure 2)