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The popular claim that the effect fades after 4 to 6 weeks so you have to cycle is a widely repeated myth with no primary study behind it, and the mechanism actually argues against a classic tolerance effect

accessed November 25, 2020

Energy levels often improve as your body gets better at using fat for fuel

However, additional data was gathered with the knockout mice that indicated that while AOD9604 did not lead to significant weight loss or increase in lipolysis without the beta(3)-adrenergic receptors, there was an increase in energy expenditure and fat oxidation

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