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TAMs secrete IL-6/TNF- to activate NOX2, which exacerbates ROS accumulation and forms a positive feedback loop of oxidative stress-ferroptosis (187)

Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity

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The presence of the AcrAB-TolC complex in K