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2.4 Combining DPI, MitoQ and vincristine induces cell death of MNA NB cells To characterize the interaction between MitoQ, DPI, and vincristine, we assessed their effects on cell death at IC50/2 and IC50/3 concentrations in four NB cell lines: Be(2)-C (MNA), IMR-32 (MNA), IMR-5/75 (MNA with MYCN downregulatable), and SH-SY5Y/MYCN (non-MNA, MYCN-inducible)

Foresta C, Ferlin A, Toni LD, Lana A, Vinanzi C, Galan A, et al

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Handling must only be performed by qualified and trained laboratory professionals in accordance with applicable regulations and institutional guidelines

While they act via identical mechanisms, AOD9604 is often preferred in oral administration studies due to its resistance to digestive enzymes, whereas standard 176-191 requires parenteral administration in research settings

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