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Endothelial dysfunction is the initial step in the pathogenesis of arteriosclerosis, resulting in cardiovascular complications

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Foam on the surface (large, persistent bubbles) indicates you either shook the vial or injected water too aggressively

Pigs with metabolic syndrome fed a high-cholesterol/carbohydrate diet showed decreased cardiolipin content, altered mitochondrial morphology and function, and increases of renal cyt c-induced apoptosis, oxidative stress, and tubular injury