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Therefore, blocking the formation of DTCs or targeting DTCs for treatment is expected to reduce the number of stable drug-resistant cells by lowering the formation of stable drug-resistant cells, which can thus improve the therapeutic outcome of tumours

[DOI] [PubMed] [Google Scholar] 78.Bella R., Ferri R., Pennisi M., Cantone M., Lanza G., Malaguarnera G., Spampinato C., Giordano D., Alagona G., Pennisi G

Additionally, downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a crucial regulator of the cellular antioxidant response, compromises the hepatocytes first-line defence against oxidative injury [50, 51]

Compared with patients without lung involvement, the occurrence of lung metastasis significantly reduces the survival of patients and increases the risk of death

[73] Superoxide dismutase is known to reverse fibrosis, possibly through de-differentiation of myofibroblasts back to fibroblasts

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