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Compounds such as thalidomide and its analogs lenalidomide and pomalidomide promote interactions between E3 ligases (e.g., cereblon) and specific target proteins, triggering their ubiquitination and proteasomal degradation

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605 It has been reported that the NAMPT protein levels in athletes skeletal muscle is much higher than in type 2 diabetic, sedentary obese and nonobese subjects