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Notably, a recent study revealed that a significant portion of acetaldehyde produced in the liver is excreted into the intestine via bile, where it is further metabolized by intestinal epithelial ALDH2 [25]

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LNP delivery of base editor mRNA has achieved over 60% hepatic editing efficiency in non-human primates, resulting in approximately 90% reduction in plasma PCSK9 levels and 60% reduction in LDL cholesterol [248, 249]

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Cohesin-mediated NF-kappaB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Furthermore, isopentenyl pyrophosphate can be utilized by a selenium protein to regulate GPX4 synthesis and increase ferroptosis sensitivity [27]