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Similar patterns show up with glutathione, curcumin, and other notoriously hard-to-absorb nutrients

doi: 10.1111/acel.13338

Nuttall et al.[37] studied the effect of chronic ingestion of therapeutic doses of APAP (1 gram, 4 times per day, for 2 weeks) on serum antioxidant capacity, and found a gradual and progressive decline to a level about 85% of control value