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In contrast, one would have predicted significantly increased serum levels of lactate and carboxylic acid markers of hypoxia (e.g., succinate) in patients with COVID-19, similar to that seen in patients following ischemic (71) or hemorrhagic shock (72)

Luxin Li, [email protected] This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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We critically analyze ongoing controversies in the field, including the debate over glycolytic versus OXPHOS dependency in NSCLC subsets, and discuss emerging therapeutic vulnerabilities such as ferroptosis

Therapeutic strategies that correct specific imbalanceswhether through chelation in overload or supplementation in deficiencyhold significant promise for mitigating HF progression