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Vitamin B12 is a cofactor in the enzymatic reaction that converts MMA to succinyl-CoA, and B12 and folic acid are co-factors in the reaction that converts homocysteine to methionine

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Formulations without preservatives must be used more quickly, often within days rather than weeks, because each puncture introduces potential contamination with no chemical defense against bacterial growth

Some groups are more likely to experience low B12 levels, even without major health issues

It also helps healthcare facilities maintain regulatory compliance while providing better documentation for quality care