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Foods rich in ellagitannins or ellagic acid If urolithin A sounds like something youre interested in, but you dont want to add another supplement to your daily regimen, then eating foods rich in its precursors could be an option.11 While ellagitannins and ellagic acid can be found in an array of fruits and nuts, the pomegranate fruit (and especially pomegranate juice) is often considered to be their best source.54 Unfortunately, this alternative only has the potential to work if youre part of the roughly 40% or so of people who can produce urolithin A after consuming these polyphenols (this depends on factors like your unique microbiome).6 And, currently, the only way to potentially find out if youre a producer or not is to apply for the Mitopure Challenge offered by Timeline

It has been found that the expression level and function of Sirt3 is selectively reduced in the spinal cord of SOD1G93A mice at the end of ALS course, while the level of Sirt3 is increased in the human spinal cord after autopsy

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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Conclusion: In this single centre Australian study, patients living further away from their LT centre had different demographics and fewer face-to-face visits during follow-up

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