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In addition, excessive MMP activity at the periphery of tophi promotes local joint destruction, whereas the dominance of TIMPs within the tophus core stabilizes the fibrotic structure

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A double-blind clinical trial with topical application of NSO observed a significant reduction in osteoarthritis pain in elderly people [268]

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Targeting protein tyrosine phosphatase non-receptor type 6 (PTPN6) as a therapeutic strategy in acute myeloid leukemia