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Moreover, the infected modeled animals should develop clinical features/morbidity (pathophysiology and clinical manifestations, i.e., signs and symptoms) that resemble human disease and the symptom severity should correlate with the viral load and demographic conditions in human (elderly and immunocompromised subjects are vulnerable to severe disease and mortality)

Obesity and CD8 T cell metabolism: implications for antitumor immunity and cancer immunotherapy outcomes

Appl Environ Microbiol 70(1):340345

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In addition, hyperoside exhibits a novel therapeutic potential for diabetic nephropathy by attenuating AGE/RAGE binding and TGF-1 expression through the inhibition of pERK1/2, p38 MAPK, and IB phosphorylation (Zhang et al., 2013