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Choline is required in the regulation of the kidneys, liver and gallbladder

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These include cardiovascular responses (tachycardia, palpitations, elevated blood pressure), central nervous system symptoms (insomnia, restlessness, jitteriness, dizziness, tremors, headache), mood changes (euphoria or irritability), and gastrointestinal effects (dry mouth, unpleasant taste, constipation, occasional diarrhea)

Neurologic symptoms as the only manifestation of B12 deficiency in a young patient with normal hematocrit, MCV, peripheral blood smear and homocysteine levels

general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively