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[10] IP3 appears to bind to receptors on the endoplasmic reticulum, releasing calcium ions, while DAG may activate protein kinase C, phosphorylating signaling molecules and amplifying the cascade

Role for the Burkholderia pseudomallei capsular polysaccharide encoded by the wcb operon in acute disseminated melioidosis

After 10 min, the needle of a Hamilton syringe, loaded with vehicle or drug solution, was inserted into the catheter, and the catheter was inserted into the orifice produced in the papilla

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This triggers a cascade of pathological events, including aberrant NMDAR ion channel kinetics, large neuronal Ca 2+ influx, and activation of pro-death signaling pathways