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323 In addition to the above two drugs, asparaginase-targeting drugs include OP-01, JZP-458, ERY-001, and PF-690

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Normal levels for NAD + , NADH, GSH pool and GSSG were determined from frozen blood samples of healthy donors

In addition to maintaining hepatic metabolic homeostasis, AMPK activation has been reported to promote mitochondrial function and suppress endoplasmic reticulum (ER) stress 22

To this end, this study therefore endeavors to investigate this cross-talk in the context of HNSCC, based on a comprehensive literature search of PubMed and Web of Science (20002025) using relevant keywords, with priority given to highly cited and preclinical studies

Even with metformins remarkable safeness and efficacy, over 38% of diabetic population still struggle to achieve glycemic targets with metformin