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10.1038/nm747 5 AyalaA.MuozM

HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis

Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1

276 Interestingly, accumulation of the BNIP3 paralog BNIP3L/NIX protein not only triggers mitophagy but also activates the mTORC1 pathway

Similar content being viewed by others Introduction B cells regulate many functions required for immune homeostasis and can present antigens very efficiently through their major histocompatibility complexes to T cells 1,2

We next assessed if alkyne-HNE can bind to NLRP3 by treating THP-1 macrophages with 3 M HNE or 10 M alkyne-HNE after inflammasome activation by nigericin