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2012;104(16):1251-1259 Schwartzbaum J

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3C), making the disulfide bond formation between GSSG and C79 or C26 less likely to occur

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Specifically, the pathogenesis of PH is driven by factors such as mutations in the type II bone morphogenetic protein receptor (BMPR2), chronic inflammation, fibrosis, immune activation, and mitochondrial metabolic dysfunction (Thenappan et al., 2018)

23 Some of the proteins released from mitochondria into the cytoplasm include apoptosis-inducing factor and endonuclease G, both of which have nuclear localization signals and thus translocate to the nucleus, where the endonuclease cleaves DNA, resulting in DNA fragmentation