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Possible negative effects of smoking on periodontal tissues may include altered neutrophil function, decreased IgG production, vascular alterations, increased prevalence of perio-pathogens, altered fibroblast attachment and functions, decreased lymphocyte proliferation, difficulty in eliminating pathogens by mechanical therapy, and negative local effects on cytokinesis and growth factor production [36]

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10.1016/j.fertnstert.2007.03.069 147 SkliutG.BauytR.BorutinskaitV.ValiulienG.KaupinisA.ValiusM.et al (2021)

Antioxid & Redox Signaling

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Mechanisms include receptor adaptation and behavioral factors