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It is important to note that the common factors which relate to all these metabolic pathologies are cytokines and oxidative stress, which have been elucidated to have a raised impact that could explain these different pathologies, being all of them interconnected

Among all OPTN mutations, E50K is the one most clearly shown to cause glaucoma

doi:10.1073/pnas.81.11.3337

Riva N, Clarelli F, Domi T, Cerri F, Gallia F, Trimarco A, et al

Commercial antibodies were purchased from the suppliers listed in Appendix Table S1

While the overall symptoms of AIH are similar across regions, notable differences exist in clinical presentation at diagnosis [4, 5, 9, 13,14,15, 30,31,32,33]